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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Corilagin, Paclitaxel
Phytochemical Name Corilagin (PubChem CID: 73568 )
Anticancer drug Name Paclitaxel (PubChem CID: 36314 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Paclitaxel
Adverse Reactions Bronchospasmodic dyspnoea, hypotension, peripheral neuropathy and bone, joint and muscle aches and pains. This was inferred cold nature anticancer drug.
Recommendations Hot: Dimocarpus longan; Terminalia chebula; Astragalus membranaceus; Lycopodium japonicum
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 446
Ref_1
Pair Name Corilagin, Paclitaxel
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Biological Phenomena Inhibition-->Glycolysis
Gene Regulation Down-regulation Expression CD44 hsa960
Down-regulation Phosphorylation MAPK1 hsa5594
Down-regulation Expression SNAI1 hsa6615
Down-regulation Expression STAT3 hsa6774
In Vitro Model KOV3.ip1 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0C84
HEY High grade ovarian serous adenocarcinoma Homo sapiens (Human) CVCL_0297
HO-8910 Human papillomavirus-related cervical adenocarcinoma Homo sapiens (Human) CVCL_6868
Result Our observations indicate that corilagin sensitized epithelial ovarian cancer cells to paclitaxel and carboplatin treatment by primarily inhibiting Snail-glycolysis pathways. Corilagin is a herbal medicine with low toxic effects to normal cells, particularly hepatoprotective, and may be an ideal complimentary medicine when combined with highly toxic chemotherapeutic agents.
03. Reference
No. Title Href
1 Corilagin sensitizes epithelial ovarian cancer to chemotherapy by inhibiting Snail‑glycolysis pathways. Oncol Rep. 2017 Oct;38(4):2464-2470. doi: 10.3892/or.2017.5886. Click
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